Vaccine To Combat Killer Meningococcal Epidemic
Government Funds Development Of Vaccine To Combat Killer Meningococcal Epidemic
Health Minister Annette King
today announced a $100 million-plus initiative to combat New
Zealand’s ongoing epidemic of meningococcal disease.
The money will be spent on developing a vaccine that will be used to immunise more than a million young New Zealanders over five years.
"I am absolutely delighted to announce this huge investment in protecting the health of young New Zealanders against this epidemic. In the past year alone, 26 New Zealanders have died, and the epidemic has affected the lives of thousands of young New Zealanders, and shows no sign of abating."
Ms King said clinical studies of a vaccine developed specifically for New Zealand would start this year, and if the outcome was successful, every New Zealander under the age of 20 would be vaccinated within the next five years.
“The Ministry of Health advised last week that in 2001 a person died every two weeks on average from meningococcal disease, making it the worst year on record since an epidemic started sweeping through New Zealand 11 years ago. There were 660 cases of meningococcal disease reported last year.
"These sorts of statistics cannot be allowed to continue. Meningococcal disease causes more hospitalisation and fatalities than any other notifiable infectious disease in New Zealand. There is a significant cost for survivors – the disabling effects can include limb amputations, massive skin grafts or brain damage.
"The estimated social cost of the disease is $75 million a year, including hospital and rehabilitation costs of about $29 million a year."
Ms King said Ministry of Health project leader Dr Jane O'Hallahan had flown to the United States this week to continue talks with the vaccine supplier, biotechnology company Chiron Corporation.
“The estimated cost of purchasing and delivering the vaccine to New Zealanders under 20 is expected to be more than $100 million over five years, but more details will be available by late March once negotiations with Chiron are complete.”
Ms King said that in developing the vaccine, specific to the strain of meningococcal group B bacterium responsible for the NZ epidemic, Chiron would collaborate with the Norwegian National Institute of Public Health (NIPH) and work with the Ministry of Health and Auckland University for the trial and vaccine delivery programme.
“An initial clinical study will be carried out with a small number of people in Auckland around mid-May. A team from Auckland University, Chiron and the ministry will oversee the study. The Norwegian involvement reflects Norway's experience in developing a vaccine to combat an epidemic of a different strain of group B meningococcal disease.
"The vaccine is going through a rigorous analysis according to international guidelines on vaccine development and the monitoring of participants. This will include assessment from the Standing Committee on Therapeutic Trials (SCOTT), Medsafe and regional ethics committees.”
Ms King said the Californian-based Chiron Corporation also has experience in developing vaccines for preventing various groups of meningococcal disease, including MenjugateTM, which was used in a universal vaccination campaign to prevent group C meningococcal disease in the United Kingdom. This vaccine has also been approved for use in Canada, Ireland and Hungary.
Ms King warned that until a vaccine was widely available in New Zealand, the public needed to be able to recognise the symptoms of meningococcal disease and to seek treatment early.
QUESTIONS AND ANSWERS
Who will be
participating in the initial study?
Details are yet to be
finalised, but it will involve volunteers.
What does the
initial clinical study involve?
The clinical study will
be overseen by a team consisting of the University of
Auckland, Chiron and the Ministry of Health. Further
details, including the number of volunteers, are yet to be
finalised. However, there are national and international
guidelines regarding clinical studies that must be met. The
prime focus of these guidelines is the safety of volunteers
in the study. The guidelines cover issues ranging from
production, vaccine quality, guidelines of selection
criteria for volunteers, ethics approval, monitoring and
auditing. Before any study can proceed, ethics approval is
required, as well as approval from the Ministry of
Health.
Details of the guidelines are documented in the
publication New Zealand Regulatory Guidelines for Medicines
Volume 3: Interim Good Clinical Research Practice Guidelines
August 1998. A full copy of this can be found on the Medsafe
website www.medsafe.govt.nz
How much is the initial study
costing New Zealand?
We still do not know what the total
cost will be as this is dependent on the initial findings
and peer review from national and international
advisors.
What happens once the initial clinical study is
complete?
The next steps will be determined pending the
outcome of the study. Details of this initial study are yet
to be finalised. The results will be assessed and planning
for the next stage will be based on these results.
How
does the situation in New Zealand compare
internationally?
New Zealand has a very high number of
people catching meningococcal disease compared with other
countries. However, of these people the proportion who die
from meningococcal disease is decreasing and among the
lowest in the world. We credit this to high levels of
community awareness about the need for speedy medical
treatment, vigilance by parents and caregivers and rapid,
effective treatment by health professionals.
What is
meningococcal disease?
Meningococcal disease is a serious
bacterial infection caused by a bacterium (germ) Neisseria
meningitidis, known as a meningococcus. It usually affects
the membrane around the brain (meningitis) or the blood
(blood poisoning). It is a serious disease and can sometimes
cause death or permanent disability such as deafness.
What
are the symptoms?
Symptoms in a very young child can
include a fever and vomiting, or the child may refuse drinks
or feeds, be excessively sleepy, or cry and be unsettled. A
rash that looks like blood spots under the skin may also
appear at a later stage. The symptoms in an adult are
similar.
What are the benefits of
immunisation?
Immunising all people under the age of 20
nationwide would see 3860 cases averted and 194 lives saved
over the 10 years that the epidemic would expect to run
without a vaccine. Eighty-five percent of cases occur in
people under 20 years of age, so it is important that all
people at serious risk of this disease are immunised.
Are
different ethnicities at greater risk of contracting
meningitis?
Rates in Maori are almost three times higher
than in the European population, while the rate in Pacific
people is almost six times higher than people of European
ethnicity. In 2001, of the 26 people who died, nine were
Maori and four were Pacific Islanders.
Rates of disease
in all ethnic groups were particularly high among those
under age five. Since mid-1991, when the current epidemic
started, there have been 4226 cases reported and 184 deaths
from meningococcal B disease.
What has been the
involvement of the World Health Organisation?
The WHO has
been actively involved and provided support to the New
Zealand Ministry of Health in the development of a strain
specific meningococcal vaccine since 1998. The WHO supports
the strategy of vaccinating all under 20 year olds in New
Zealand to control the current epidemic. The WHO will be
providing advice to the New Zealand Government in assisting
with the clinical trial process and the implementation of a
mass vaccination campaign.
How is meningococcal disease
spread?
Up to 20 percent of the population or 750,000 New
Zealanders carry the meningococcal bacterium in their nose
and throat and while not all carriers get sick, babies and
young children are particularly at risk of developing blood
poisoning or meningitis (swelling of the brain) from this
bacterium.
The bacterium can be spread by close contact
with someone who is carrying it, such as living in the same
household or sharing food, drink or utensils, so those in
accommodation such as student hostels are also more
susceptible.
KEY MESSAGES FOR MENINGOCOCCAL
DISEASE
Don't wait – take action: see a doctor
if you or your child is sick
If your child is
sick check them often
Your child may be
seriously ill if they:
o Have a fever
o Refuse drinks
or feeds
o Are sleepy or floppy – or harder to wake
o
Vomit
o Are crying or unsettled
o Have a
rash/spots
o Have a headache
Doctor's visits
are free for children under six
Anyone can get
meningococcal disease – though those at greatest risk are
children under five and young adults
If your
child gets worse – take them straight back to the
doctor.
REGIONAL BREAKDOWN OF MENINGOCOCCAL CASES IN
NEW ZEALAND
Region 2000 2001
Northland 26 37
North
West Auckland 39 37
Central Auckland 77 80
South
Auckland 118 126
Waikato 45 76
Eastern Bay of
Plenty 13 15
Rotorua 10 26
Tauranga 12 15
Gisborne 12 11
Taupo 2 12
Ruapehu 3 2
Hawke's
Bay 18 28
Taranaki 5 10
Manawatu 8 20
Wanganul 8 6
Wellington 18 24
Wairarapa 6 11
Hutt 10 17
Nelson-Marlborough 5 12
Canterbury 19 20
South
Canterbury 4 3
West
Coast 0 3
Otago 17 55
Southland 5 12
LOCATION OF
MENINGOCOCCAL DEATHS BY HEALTH DISTRICT BY YEAR
Health
District 1996 1997 1998 1999 2000 2001
Canterbury 1 2 2 1 1
Central
Auckland 1 1 3 3 2 2
Eastern Bay of
Plenty 1
Gisborne 1 1
Hawkes
Bay 2 1 2 1
Hutt 2 2 2 1
Manawatu 1 1 1
Nelson-Malborough 1 3 2
North
West
Auckland 3 2 1 1 1
Northland 3 2 3 1
Otago 1 1 1 2
Rotorua 1 1
Ruapehu 1 2
South
Auckland 3 8 2 5 2 4
South
Canterbury 1 1 2 1
Southland 1 1 1 1
Taranaki 2 1
Taupo 1
Tauranga 1 1 1 3
Waikato 1 3 5
Wairarapa 1
Wanganui 1
Wellington 3 1
West
Coast 1
Total 18 24 23 22 17 26