News Video | Policy | GPs | Hospitals | Medical | Mental Health | Welfare | Search

 


Aspirin a viable treatment for serious blood clots


5 November, 2012

Aspirin a viable treatment for serious blood clots, study shows

Low-dose aspirin is a cheap and effective way to prevent potentially deadly blood clots in the leg or the lungs in patients who have had a previous blood clot a new study shows.

The study, conducted by the National Health and Medical Research Council’s Clinical Trials Centre at the University of Sydney, and a team of international investigators, is published today in The New England Journal of Medicine.

The study has found that people who have suffered blood clots in the veins of the leg (deep vein thrombosis or DVT) or the lungs (pulmonary embolism or PE) are less likely to suffer a recurrence of the serious blood clots or a cardiac event if they take low-dose aspirin. These conditions affect approximately 1 in 1000 people in Australia each year.

“The results of this study suggest the simple, inexpensive treatment of low-dose aspirin could prevent thousands of patients from experiencing recurrent clots each year and may make substantial healthcare savings in Australia and worldwide,” Professor John Simes, Director of the NHMRC Clinical Trials Centre at the University of Sydney and chair of the study said.

“These results suggest that aspirin prevents about one third of recurrent blood clot events. For every 1000 patients treated for one year, aspirin can be expected to prevent about 20 to 30 episodes of recurrent major thrombotic events at the cost of about 3 significant bleeding episodes.”

Operating since 2003, the ASPIRE study completed recruitment of 822 participants from five countries including Australia, New Zealand, Singapore, India and Argentina. All the participants had previously suffered a DVT or PE that occurred for no particular reason, called ‘unprovoked VTE’ (venous thromboembolism).

They had completed on average six months of anti-coagulant treatment, generally with warfarin. They were randomly allocated to receive either low dose enteric coated aspirin or a matching placebo. On average participants were followed for three years.

Dr Tim Brighton, from Prince of Wales Hospital and principal investigator of the study, explained:

“Many patients discontinue warfarin therapy after six or twelve months of treatment due to the inconvenience of regular blood tests and the increased risks of serious bleeding [putting them at high risk of recurring thrombosis].”

“Aspirin reduces the risk of important blood clotting event including recurrent VTE, myocardial infarction, stroke, or cardiovascular death. We now have clear evidence that aspirin is of benefit for patients who are unable or do not wish to continue warfarin in the long term.”

The study results are consistent with the findings of an Italian study, called WARFASA, which a showed a significant benefit with aspirin as reported in the The New England Journal of Medicine earlier this year.

When combined, the results of the two trials show clear and consistent evidence that aspirin prevents recurrent blood clots and this is likely to be adopted into future international practice.

© Scoop Media

 
 
 
 
 
Culture Headlines | Health Headlines | Education Headlines

 

Bodega: Venue Closing At The End Of The Year, After 25 Years Of Music

"It is with considerable sadness that, for reasons beyond our control, we regret to announce the closure of Bodega’s doors at the end of this year, after 25 years of faithful and committed service to live music in Wellington." More>>

Memorabilia: Te Papa Buys Peter Snell Singlet

Te Papa has purchased the singlet worn by Peter Snell at the 1964 Tokyo Olympics at an auction this morning at Cordy’s auction house in Auckland. More>>

ALSO:

Scoop Review Of Books: Women At The Centre

In the first chapter of her epic History of New Zealand Women, Barbara Brookes places a version of the Māori creation story alongside that of the Pākehā colonists, setting the scene for how each society saw women. The contrast is startling. More>>

In Auckland Art Gallery: A Tour Of Duty

I had already started my journey through the exhibited collections when an audio announcement about a guided tour to embark shortly from the foyer was made, I decided to join in. Why not? More>>

Art: ‘Holiday’ Wins IHC Art Awards

An intricate embroidered cushion by Wellington artist Jo-Anne Tapiki has won the 2016 IHC Art Awards and $5000. Jo-Anne started working from IHC’s Arts on High studio in Lower Hutt 18 months ago and this is the first time she has entered the competition. More>>

‘Quasi’: Christchurch Art Gallery Reveals Rooftop Sculpture

Christchurch-born and internationally renowned artist Ronnie van Hout has had a huge hand in Christchurch Art Gallery's latest outdoor installation. More>>

Get More From Scoop

 
 

LATEST HEADLINES

 
 
 
 
Health
Search Scoop  
 
 
Powered by Vodafone
NZ independent news