News Video | Policy | GPs | Hospitals | Medical | Mental Health | Welfare | Search

 


Funding for research into new wave of breast cancer drugs

Monday 4 August 2014

Funding awarded for research into new wave of breast cancer drugs

University of Otago research aimed at developing drugs that are selectively lethal to cancer cells is one of two newly funded innovative projects which share the goal of improving and ultimately ensuring breast cancer survival in New Zealand.

Professor Parry Guilford of the Department of Biochemistry has gained about $200,000 from the Breast Cancer Research Partnership for a two-year project he is leading, titled “Synthetic lethal targeting of lobular breast cancer”.

Lobular breast cancer is the second most common type of the disease.

Healthy cells produce E-cadherin, a protein that suppresses tumour growth, but the gene that produces E-cadherin is often ‘switched off’ in cancer cells. Professor Guilford and his team are searching for compounds that will destroy cells lacking E-cadherin, but not healthy cells with normal levels of the protein.

The team is collaborating with the Walter and Eliza Hall Institute and the Peter MacCallum Cancer Centre, in Melbourne, to screen for drugs active against this target. The researchers predict that these new drugs will produce fewer side effects than standard chemotherapies.

This project was originally submitted to the Breast Cancer Research in New Zealand initiative, which is a joint funding partnership between Breast Cancer Cure Research Trust, The New Zealand Breast Cancer Foundation and the Health Research Council.

Project description:

Synthetic lethal targeting of lobular breast cancer

24 months, $199,792 (funded by the HRC, Breast Cancer Cure and The New Zealand Breast Cancer Foundation)

The inactivation of tumour suppressor genes is the most common of all genetic events in cancer but not one that can be targeted by conventional therapy, because the tumour suppressor protein is lost from the cancer cell. However, the loss of these genes is predicted to create vulnerabilities in the cancer cell that can nevertheless be targeted with drugs.

Professor Guilford will use existing data showing that the loss of the tumour suppressor gene CDH1, an event that is a hallmark of the lobular subtype of breast cancer, creates vulnerabilities which can be targeted with drugs. He will lead a research project that will develop new breast cancer treatments which exploit these vulnerabilities.


© Scoop Media

 
 
 
 
 
Culture Headlines | Health Headlines | Education Headlines

 

Architecture:
Ian Athfield Dies In Wellington

New Zealand Institute of Architects: It is with great sadness that we inform Members that Sir Ian Athfield, one of New Zealand's finest architects, has passed away in Wellington. More>>

ALSO:

Wellington Production: New-Look Tracy Brothers Are F.A.B.

ITV and New Zealand’s Pukeko Pictures today released an exclusive preview of the new-look Tracy brothers from this year’s hotly anticipated new series, Thunderbirds Are Go. More>>

ALSO:

Cardinal Numbers:
Pope Francis Names Archbishop From NZ Among New Cardinals

Announcing a list of bishops to be made Cardinals in February Pope Francis named Archbishop John Dew, Archbishop of Wellington, overnight from Rome. On hearing the news of the announcement, Archbishop John Dew said "This news is recognition of the Catholic Church in Aotearoa New Zealand, and the contribution it makes to the global Catholic family." More>>

ALSO:

Nomenclature: Charlotte And Oliver Top Baby Names For 2014

Charlotte and Oliver were the most popular names for newborn girls and boys in 2014... The top 100 girls’ and boys’ names make up a small proportion of the more than 12,000 unique first names registered for children born this year, says Jeff Montgomery, Registrar-General of Births, Deaths and Marriage. More>>

Werewolf: Katniss Joins The News Team

From the outset, the Hunger Games series has dwelt obsessively on the ways that media images infiltrate our public and personal lives... From that grim starting point, Mockingjay Part One takes the process a few stages further. There is very little of the film that does not involve the characters (a) being on screens (b) making propaganda footage to be screened and (c) reacting to what other characters have been doing on screens. More>>

ALSO:

Scoop Review Of Books: Ko Witi Te Kaituhituhi

Witi Ihimaera, the distinguished Māori author and the first Māori to publish a book of short stories and a novel, has adopted a new genre with his latest book. But despite its subtitle, this book is a great deal more than a memoir of childhood. More>>

Werewolf: Rescuing Paul Robeson

Would it be any harder these days, for the US government to destroy the career of a famous American entertainer and disappear them from history – purely because of their political beliefs? You would hope so. In 1940, Paul Robeson – a gifted black athlete, singer, film star, Shakespearean actor and orator – was one of the most beloved entertainers on the planet. More>>

ALSO:

"Not A Competition... A Quest": Chapman Tripp Theatre Award Winners

Big winners on the night were Equivocation (Promising Newcomer, Best Costume, Best Director and Production of the Year), Kiss the Fish (Best Music Composition, Outstanding New NZ Play and Best Supporting Actress), and Watch (Best Set, Best Sound Design and Outstanding Performance). More>>

ALSO:

Get More From Scoop

 
 

LATEST HEADLINES

 
 
 
 
Health
Search Scoop  
 
 
Powered by Vodafone
NZ independent news