News Video | Policy | GPs | Hospitals | Medical | Mental Health | Welfare | Search

 


Malaghan Institute unravels mysteries of allergic response

18 August 2014

Malaghan Institute unravels mysteries of allergic response

Researchers at the Malaghan Institute of Medical Research in Wellington are a step closer to unravelling some of the mysteries surrounding what triggers an allergic response.

Research headed by Professor Franca Ronchese and now published in the Journal of Immunology, concludes that allergies change the properties of a certain type of dendritic cell found in the skin. It’s the dendritic cell that then tells the immune system how to respond.

“This study is significant because, while we know a lot about the symptoms of allergies, comparatively little is understood about the detail of what starts an allergic response,” says Doctor Lisa Connor, Research Fellow at the Malaghan Institute’s Immune Cell Biology Programme.

“This research is exciting news for the Malaghan Institute. Years of research around the world demonstrate that dendritic cells play a key role in the immune system owing to their ability to control both immune tolerance and immunity. The ultimate goal of a team of researchers at the Institute is to use these new discoveries to develop ways of generating therapeutic immunotherapies against allergies. In essence, Malaghan Institute researchers are seeking an “off switch” for allergic responses.”

Whilst the progress reported in the paper fills a gap in our knowledge, many challenges remain. For many diseases, including allergies, key pieces of the immune pathways remain unclear. It is now recognised that there is a progression of disease; children with dermatitis are more likely to develop food allergies, followed by respiratory allergies such as asthma and hay fever. This progression is called the ‘allergic march’. It is thought that by inhibiting the early development of allergic diseases the likelihood of more severe forms occurring later in life should decrease.

The research focused on the skin, so next steps will include looking at dendritic cells in the gut and lungs; as well as developing a detailed inventory of their characteristics and behaviour.

Allergies are very common and affect about one in three New Zealanders at some time in their lives. The incidence of allergic diseases has increased significantly over the last two and a half decades, and is regarded to be a global epidemic.

This study was supported by the Health Research Council of New Zealand.

Publication details
Connor LM, Choot Tang S, Camberis M, Le Gros G, Ronchese F (2014) Helminth-conditioned dendritic cells prime CD4+ T cell to IL-4 production in vivo. Journal of Immunology.
http://www.ncbi.nlm.nih.gov/pubmed/?term=ronchese+connor#

About the Malaghan Institute of Medical Research
The Malaghan Institute of Medical Research is New Zealand’s leading vaccine and immunology research institute and is based at Victoria University of Wellington’s Kelburn campus. The Institute operates independently and is a charitable trust. Researchers at the Malaghan Institute are focused on developing innovative ways to harness the strength and potency of the immune system, the body’s own natural defence against disease, to treat cancer, asthma and allergy, arthritis, multiple sclerosis and infectious disease.

ENDS

© Scoop Media

 
 
 
 
 
Culture Headlines | Health Headlines | Education Headlines

 

Theatre: Ralph McCubbin Howell Wins 2014 Bruce Mason Award

The Bruce Mason Playwriting Award was presented to Ralph McCubbin Howell at the Playmarket Accolades in Wellington on 23 November 2014. More>>

ALSO:

One Good Tern: Fairy Tern Crowned NZ Seabird Of The Year

The fairy tern and the Fiji petrel traded the lead in the poll several times. But a late surge saw it come out on top with 1882 votes. The Fiji petrel won 1801 votes, and 563 people voted for the little blue penguin. More>>

Music Awards: Lorde Reigns Supreme

Following a hugely successful year locally and internationally, Lorde has done it again taking out no less than six Tuis at the 49th annual Vodafone New Zealand Music Awards. More>>

ALSO:

EPMU: Fourth Pike River Anniversary

Representatives of the Engineering, Printing and Manufacturing Union are proud to stand with the Pike River families to mark four years since 29 men lost their lives. More>>

ALSO:

'Kindara': Unusual Ginger Coloured Kiwi Chick Released To Taupo Creche

A cute little kiwi chick with an unusual ginger tinge to its feathers has just been released to Wairakei Golf & Sanctuary Kiwi Creche in Taupo after hatching at Rainbow Springs' Kiwi Encounter. More>>

Werewolf: The Complicatist : Bob Dylan Himself, And By Others

Bob Dylan is about to release a six CD version of the entire Basement Tapes sessions he recorded with the Band 40 years ago. To mark the occasion, I’ve rustled together some favourite cover versions of Dylan songs, and a few lesser-known tracks by the great man. More>>

ALSO:

Werewolf: Gone Girl : The Trouble With Amy

Philip Matthews: Three words to describe the David Fincher film Gone Girl: cynical, topical and ridiculous. Ridiculous isn’t a negative. More>>

ALSO:

11/11: Armistice Day Peace Vigils

On Armistice Day 2014, the second in the series of peace vigils that will take place three times each year during the World War One centenary will be held in Hokianga, Whangarei, Auckland, Tauranga, Otaki, Lower Hutt, Wellington and Takaka. More>>

ALSO:

Get More From Scoop

 
 

LATEST HEADLINES

 
 
 
 
Health
Search Scoop  
 
 
Powered by Vodafone
NZ independent news