News Video | Policy | GPs | Hospitals | Medical | Mental Health | Welfare | Search

 

KEYTRUDA trial demonstrates effectiveness


10th May 2019. A new analysis of the KEYNOTE-189 trial was recently presented at the American Association for Cancer Research (AACR) meeting and showed KEYTRUDA® (pembrolizumab) had a similar effect on lung cancer patients whose tumours had spread to the brain and liver, compared to those whose tumours hadn’t spread.1

The KEYNOTE-189 study evaluated KEYTRUDA in combination with platinum-based and pemetrexed (ALIMTA®) chemotherapies compared with the chemotherapy combination alone, for untreated patients with advanced non-squamous non-small cell lung cancer (NSCLC).

The retrospective evaluation of the study looked at the sub-groups of NSCLC patients with liver and/or brain metastases at the start of the trial.2 It showed that patients with NSCLC that had spread to these sites, who then received KEYTRUDA plus chemotherapy, had a median overall survival which was at least twice that of patients receiving chemotherapy alone; with 19.2 months versus 7.5 months for those with brain metastases and 12.6 months versus 6.6 months for those with liver metastases. At the time, the clinical trial had studied these patients for a median of 18.7 months.1

Merck Sharp & Dohme, NZ Director, Mr Smith says, “This analysis shows that patients still benefited from the combination of KEYTRUDA and chemotherapy as a first line treatment. New Zealand was the second country worldwide to register KEYTRUDA in combination with chemotherapy for untreated advanced non-small cell lung cancer, however it is not yet funded by PHARAMC.3

“Despite successful trial results and lung cancer being the leading cause of cancer death in New Zealand; patients are only currently funded to receive chemotherapy.

“KEYTRUDA was funded for New Zealand melanoma patients in 2016;4 and we made our first lung cancer submission to PHARMAC more than two years ago. KEYTRUDA is now funded for lung cancer in 42 countries worldwide, including Romania, Greece and Lebanon. 3

“There is nothing to stop PHARMAC from funding KEYTRUDA tomorrow. We know these patients don’t have time to wait.”

© Scoop Media

 
 
 
Culture Headlines | Health Headlines | Education Headlines

 

Birds: Dunedin's Bells Ring As City Celebrates Its Albatross

The city's churches, schools and public buildings bells would chime in unison from 1pm, in what has been a long-standing tradition marking the return of the birds - and a farewell to this season's albatross chicks. More>>

Oscar Buzz: Waititi's Jojo Rabbit Wins People's Choice Award At Toronto

Taika Waititi's new film Jojo Rabbit has nabbed the coveted Grolsch People's Choice Award at the close of Toronto International Film Festival. More>>

ALSO:

Broken Estate: An Expat Expert Surveys Our Media

Melanie Bunce cut her teeth in journalism at the Otago Daily Times. Now she teaches and researches it at one of the UK’s most prestigious journalism schools and tracks the trends that shape the uncertain future of news... More>>

Controversial Reforms: Te Papa Chief Executive To Step Down

Te Papa’s Chief Executive Geraint Martin announced today he will step down from the role at the end of the year. Mr Martin said he had achieved what he set out to do at the museum, and Te Papa was in a strong position for the future. More>>

ALSO:

 
 
 
 
 

LATEST HEADLINES

  • CULTURE
  • HEALTH
  • EDUCATION
 
 
  • Wellington
  • Christchurch
  • Auckland