Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Treatment for ryegrass staggers proceeds apace

AgResearch scientists overcome first hurdle in finding treatment for ryegrass staggers

24 November 2008

Two AgResearch scientists’groundbreaking research into ryegrass staggers is featuring in the December issue of The Journal of Pharmacology and Experimental Therapeutics – an American publication that focuses on novel discoveries in pharmacology.

The research done by Forage Scientists, Dr Julie Dalziel and Dr Sarah Finch and their teams, in collaboration with a group of US researchers, looks at how toxins cause ryegrass staggers. Through this research, which was funded by a grant from the Marsden Fund (Royal Society of NZ) to Drs Dalziel and Finch, scientists finally know the mechanism that causes this condition.

Ryegrass staggers is characterised by muscle tremors and poor muscle coordination. The disease was first reported in the 1880s and is thought to cost New Zealand agriculture $100 million annually in lost animal production.

Building on previous research by various scientists within AgResearch, Drs Dalziel and Finch have now discovered the biological receptor that the toxin acts on to cause this neurological disorder. “We knew the cause, but we didn’t know how the tremor-causing compounds were having their effect,” says Dr Finch.

Drs Finch and Dalziel focussed on an ion channel called the BK Channel. Ion channels are responsible for the electrical signalling that underlies movement, sensation and thought. An ion channel that has a specialized role in regulating this electrical signalling is the BK channel (large conductance calcium-activated potassium channel).

Dr Finch says through using mice that did not have BK channels (bred by their collaborators at Stanford University) they have discovered that without a BK channel the toxins didn’t have an effect on animals. She explains that the experiments involved giving mice lolitrem B (the toxin produced by the endophytic fungus). “Ordinary mice gave a tremor response similar to ryegrass staggers while mice without BK channels gave no response,”she says. “This discovery is of great significance and over a century after the first report of ryegrass staggers, the mechanism of tremor production is finally known. This means we can now start looking at ways to treat ryegrass staggers by reversing the effect or preventing it from happening altogether.”

Dr Dalziel says their findings also provide valuable insight into human disorders of motor function. “These findings could be useful from a pharmaceutical viewpoint, as they suggest new therapies for human neural dysfunction of tremor and impaired motor coordination and balance,” she says.


ENDS

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Must Sell 20 Petrol Stations: Z Cleared To Buy Caltex Assets

Z Energy is allowed to buy the Caltex and Challenge! petrol station chains but must sell 19 of its retail sites and one truck-stop, the Commerce Commission has ruled in a split decision that acknowledges possible retail price coordination between fuel retailers occurs in some regions. More>>

ALSO:

Huntly: Genesis Extends Life Of Coal-Fuelled Power Station To 2022

Genesis Energy will keep its two coal and gas-fired units at Huntly Power Station operating until 2022, having previously said they'd be closed by 2018, after wringing a high price from other electricity generators who wanted to keep them as back-up. More>>

ALSO:

Dammed If You Do: Ruataniwha Irrigation Scheme Hits Farmer Uptake Targets

Enough Hawke's Bay farmers have signed up for water from the proposed Ruataniwha Water Storage Scheme for it to go ahead as long as a cornerstone institutional capital investor can be found to back it, its regional council promoter announced. More>>

ALSO:

Reserve Bank: OCR Stays At 2.25%

Reserve Bank governor Graeme Wheeler kept the official cash rate at 2.25 percent, in a decision traders had said could go either way, while predicting inflation will pick up as the slump in oil prices washes out of the data and capacity pressures start to build in the economy. More>>

ALSO:

Export Values Down: NZ Posts Biggest Annual Trade Deficit In 7 Years

New Zealand has recorded its biggest annual trade deficit since April 2009, reflecting weaker prices of agricultural commodities such as dairy products, beef and lamb, and increased imports of vehicles and machinery. More>>

ALSO:

Currency Events: NZ's New $5 Note Wins International Banknote Award

New Zealand’s new Brighter Money $5 note has been named Banknote of the Year in a prestigious international competition. The $5 note was awarded the IBNS Banknote of the Year title at the International Bank Note Society’s annual meeting. More>>

ALSO:

Get More From Scoop

 
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news