Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


New Mechanism May Explain Genetic Susceptibility to Diabetes

New Mechanism Regulating Insulin Secretion May Explain Genetic Susceptibility To Diabetes

Media release

Maurice Wilkins Centre for Molecular Biodiscovery
A Centre of Research Excellence hosted by The University of Auckland

and

Faculty of Medical and Health Science The University of Auckland

4 February 2013

New mechanism regulating insulin secretion may explain genetic susceptibility to diabetes

New Zealand research revealing a new mechanism for how glucose stimulates insulin secretion may provide a new explanation for how a gene that makes people more susceptible to diabetes – called TCF7L2 – actually contributes to the disease.

“It has long been known that insulin is secreted from beta-cells in the pancreas, in response to rising blood glucose levels, and that the insulin in turn controls glucose levels,” explains team leader Professor Peter Shepherd from the Maurice Wilkins Centre for Molecular Biodiscovery and The University of Auckland. “However the mechanisms controlling insulin secretion have not been fully understood.”

The latest research in Professor Shepherd’s laboratory has revealed the missing link in a series of chemical signals by which glucose stimulates insulin secretion from beta-cells. The scientists found that a signalling molecule called cyclic-AMP acts to stabilise beta-catenin, a protein they show has an important role in regulating beta-cell function, including the release of insulin in response to glucose.

“This is important as Type-2 diabetes is increasing to epidemic proportions worldwide. It is caused by defective insulin release from beta-cells, and the resulting failure to control blood glucose levels. In order to understand the disease it’s important to learn about the mechanism that control insulin secretion,” says lead researcher Dr Emmanuelle Cognard, also from The University of Auckland.

This newly discovered signalling pathway may explain how one of the major diabetes susceptibility genes, called TCF7L2, can impair insulin secretion, as TCF7L2 redirects beta-catenin away from the cell surface and so would reduce the effect of beta-catenin on insulin secretion. The research is likely to influence the way new drugs to treat Type-2 diabetes are designed.

The research, which was funded by the Health Research Council of New Zealand, has been published in the February 2013 issue of the Biochemical Journal.

Notes

The Maurice Wilkins Centre is New Zealand’s Centre of Research Excellence for the discovery of new treatments and diagnostics for human disease. It brings together leading biologists, chemists, and computer scientists to target serious diseases, focusing on infectious disease, cancer and diabetes. It includes researchers with world-class reputations for designing new drugs for these diseases, several of which are in clinical trials.

The Maurice Wilkins Centre is hosted by The University of Auckland and incorporates researchers from six New Zealand Universities, three Crown Research Institutes and a private research institute: The University of Auckland, University of Otago, Victoria University, University of Waikato, University of Canterbury, Massey University, Industrial Research Limited, Plant & Food Research, AgResearch, and the Malaghan Institute of Medical Research.

www.mauricewilkinscentre.org

ENDS

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Power Outages, Roads Close: Easter Storm Moving Down Country

The NZ Transport Agency says storm conditions at the start of the Easter break are making driving hazardous in Auckland and Northland and it advises people extreme care is needed on the regions’ state highways and roads... More>>

ALSO:

Houses (& Tobacco) Lead Inflation: CPI Up 0.3% In March Quarter

The consumers price index (CPI) rose 0.3 percent in the March 2014 quarter, Statistics New Zealand said today. Higher tobacco and housing prices were partly countered by seasonally cheaper international air fares, vegetables, and package holidays. More>>

ALSO:

Notoriously Reliable Predictions: Budget To Show Rise In Full-Time Income To 2018: English

This year’s Budget will forecast wage increases through to 2018 amounting to a $10,500 a year increase in average full time earnings over six years to $62,200 a year, says Finance Minister Bill English in a speech urging voters not to “put all of this at risk” by changing the government. More>>

ALSO:

Prices Up, Volume Down: March NZ House Sales Drop 10% As Loan Curbs Bite

New Zealand house sales dropped 10 percent in March from a year earlier as the Reserve Bank’s restrictions on low-equity mortgages continue to weigh on sales of cheaper property. More>>

ALSO:

Scoop Business: Chorus To Appeal Copper Pricing Judgment

Chorus will appeal a High Court ruling upholding the Commerce Commission’s determination setting the regulated prices on the telecommunications network operator’s copper lines. More>>

ALSO:

Earlier:

Cars: Precautionary Recalls Announced For Toyota Vehicles

Toyota advises that a number of its New Zealand vehicles are affected by a series of precautionary global recalls. Toyota New Zealand General Manager Customer Services Spencer Morris stressed that the recalls are precautionary. More>>

ALSO:

'Gardening Club': Air Freight Cartel Nets Almost $12 Million In Penalties

The High Court in Auckland has today ordered Swiss company Kuehne + Nagel International AG to pay a penalty of $3.1 million plus costs for breaches of the Commerce Act. Kuehne + Nagel’s penalty brings the total penalties ordered in this case to $11.95 million ... More>>

ALSO:

Crown Accounts: Revenue Below Projections

Core Crown tax revenue has increased by $1.9 billion (or 5.0%) compared to the same time last year. However this was $1.1 billion less than expected and is reflected across most tax types, continuing the pattern of recent months. More>>

ALSO:

Get More From Scoop

 
 
Computer Power Plus
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news