Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Widely used medicicines increase risk of rare kidney disease

Widely used heartburn and peptic ulcer medicines increase risk of rare kidney disease: Otago research


New Zealanders taking a proton pump inhibitor (PPI), a type of medicine used to treat gastric acid reflux disorders and peptic ulcer disease, are at an increased risk of a rare kidney disease, according to new findings by University of Otago researchers.

In a newly published study in the journal Kidney International, the researchers found that people who were currently taking a PPI (omeprazole, pantoprazole, or lansoprazole) were about five times more likely to be admitted to hospital with interstitial nephritis than similar people who were past users of a PPI.

Study co-author Dr Lianne Parkin says that interstitial nephritis is a rare, but potentially serious condition, involving inflammation of the kidney tissue.

“While PPIs have been shown to be an effective treatment for gastro-oesophageal reflux and peptic ulcer diseases, there is also evidence, from New Zealand and overseas, which suggests these drugs are sometimes inappropriately prescribed.

“Previous studies have suggested that PPIs increase the risk of interstitial nephritis, however our study is the largest to date and the first to confirm the relationship. We were also able to calculate the absolute risk associated with these drugs, which provides useful information for patients and doctors,” says Dr Parkin. “For example, for every 100,000 people taking a PPI, we found that about 12 per year developed interstitial nephritis as compared with 2 per 100,000 among past users.”

“The excess risk of interstitial nephritis we observed in current users of PPIs, although low in absolute terms, is important from a population perspective as PPIs are one of the most widely prescribed groups of drugs – for instance, about 20% of the New Zealand population was dispensed a PPI at least once between 2005 and 2009. In addition, New Zealanders have been able to purchase a PPI over the counter, without medical advice, since late 2009,” says Dr Parkin.

The researchers used routinely collected health and prescription medicine data to conduct a study based on 572,661 people of all ages who were dispensed omeprazole, pantoprazole, or lansoprazole at any time between 2005 and 2009. Patients with pre-existing kidney disease were excluded from the study, and other potential influences, including age, sex, and other medical conditions and prescription drugs, were taken into account in the analyses.

“Although the PPIs included in our study are extremely safe for the vast majority of users,” says Dr Parkin, “it is important for prescribers to be aware of this increased risk of interstitial nephritis, and for patients to seek appropriate advice before using these medicines.”

The research was funded by Medsafe and the Health Research Council of New Zealand.

Ends

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

I Sing The Highway Electric: Charge Net NZ To Connect New Zealand

BMW is turning Middle Earth electric after today announcing a substantial contribution to the charging network Charge Net NZ. This landmark partnership will enable Kiwis to drive their electric vehicles (EVs) right across New Zealand through the installation of a fast charging highway stretching from Kaitaia to Invercargill. More>>

ALSO:

Watch This Space: Mahia Rocket Lab Launch Site Officially Opened

Economic Development Minster Steven Joyce today opened New Zealand’s first orbital launch site, Rocket Lab Launch Complex 1, on the Mahia Peninsula on the North Island’s east coast. More>>

Earlier:

Marketing Rocks!
Ig Nobel Award Winners Assess The Personality Of Rocks

A Massey University marketing lecturer has received the 2016 Ig Nobel Prize for economics for a research project that asked university students to describe the “brand personalities” of three rocks. More>>

ALSO:

Nurofen Promotion: Reckitt Benckiser To Plead Guilty To Misleading Ads

Reckitt Benckiser (New Zealand) intends to plead guilty to charges of misleading consumers over the way it promoted a range of Nurofen products, the Commerce Commission says. More>>

ALSO:

Half A Billion Accounts, Including Xtra: Yahoo Confirms Huge Data Breach

The account information may have included names, email addresses, telephone numbers, dates of birth, hashed passwords (the vast majority with bcrypt) and, in some cases, encrypted or unencrypted security questions and answers. More>>

ALSO:

Rural Branches: Westpac To Close 19 Branches, ANZ Looks At 7

Westpac confirms it will close nineteen branches across the country; ANZ closes its Ngaruawahia branch and is consulting on plans to close six more branches; The bank workers union says many of its members are nervous about their futures and asking ... More>>

Interest Rates: RBNZ's Wheeler Keeps OCR At 2%

Reserve Bank governor Graeme Wheeler kept the official cash rate at 2 percent and said more easing will be needed to get inflation back within the target band. More>>

ALSO:

Get More From Scoop

 
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news