Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


New processes identified for killing cancer cells

New processes identified for killing cancer cells

Media Release
University of Auckland
22 May 2014

New processes identified for killing cancer cells

The cell processes used by a traditional Asian health food supplement to inhibit the growth of prostate cancer cells, have been discovered by a University of Auckland researcher.

The research by Masters student, Ben Kao, involved comparing the impact of different ethanol and water based extracts of Ganoderma lucidium on cell lines of prostate cancer, and identifying how this compound kills cancer cells and reduces inflammation.

Ganoderma is a genus of the polypore mushrooms which grow on wood and include about 80 species, many from tropical regions. They are often referred to as shelf mushrooms or bracket fungi.

Genes associated with cell proliferation, cell cycle, and apoptosis (the process of cell death), were found by Ben, to have significant changes in their expression levels after treatment with the extracts.

The mushroom, Ganoderma lucidium or Lingzhi as it is known in China (Reishi in Japan), is widely available in Asian countries and has been used for millennia in Chinese medicine to promote good health.

They are available in Asia in a variety of forms and strengths, from low-strength pills to high quality red mushroom extract. The strength of the Ganoderma product can depend on how it is extracted and treated. Claims often made about Ganoderma lucidium are that the product will boost the immune system, improve circulation, reduce cholesterol, lower blood pressure, destroy tumours, and slow aging.

Research student, Ben Kao has had two scientific papers published recently on Ganoderma lucidium and its anti-cancer properties. The first published last year, was a literature review on the anti-cancer properties of Ganoderma lucidium – its active ingredients and pathways of activity.

This month, he has published a study comparing the gene expression profiles and pathway networks after treating prostate cancer cell lines with the different Ganoderma lucidium extracts.

“Ganoderma lucidium has been seen to have a growth inhibitory effect on prostate cancer, but most of the research has tested only one type of extract,” says Ben. “For this study we compared four different extraction methods to see which is the most powerful and to see how it exerts its effects.”

Two extracts were made using ethanol based extraction and two used water based extraction methods.

“The ethanol based extracts had the more direct effect on cancer cell growth by inhibiting the cell cycle and were more powerful than water based extracts,” says Ben. “For the water based extracts, the mechanism of action involved the immune and anti-inflammatory pathways within the cell.”

The Ganoderma lucidium was shown to have a strong effect on limiting cell growth in the cancer cell lines and has no negative effect on normal cell lines.

This study was completed for Ben’s Master’s thesis in the Discipline of Nutrition and the Auckland Cancer Society Research Centre at the University of Auckland, and supervised by ACSRC research fellow, Dr Karen Bishop. He has submitted a preliminary PhD proposal to continue with research on Ganoderma lucidium and this will focus on the impact of extracts in more advanced biological models.

For more details of the published study go to this link.

ENDS

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Scoop Business: Alex Swney Pleads Guilty To $2.5M Fraud Charge

Alex Swney, former chief executive of the Auckland city centre business association Heart of the City, has pleaded guilty to dishonestly using documents to obtain $2.5 million. More>>

ALSO:

Petrol Burns Prices: Second Consecutive Quarterly Fall For CPI

The consumers price index (CPI) fell 0.3 percent in the March 2015 quarter, following a 0.2 percent fall in the December 2014 quarter, Statistics New Zealand said today. The last time the CPI showed two consecutive quarterly falls was in the December 1998 and March 1999 quarters. More>>

ALSO:

Scoop Business: NZ Broadcasters Launch Battle Against Global Mode ISPs

New Zealand broadcasters have confirmed they’ve launched legal proceedings against internet service providers who give customers’ access to “global mode”, which allows customers access to offshore online content, claiming it breaches the local content providers’ copyright. More>>

ALSO:

Sanford: Closure Of Christchurch Mussel Processing Plant Confirmed

The decision comes after a period of consultation with the 232 staff employed at the Riccarton site, who were told on 9 April that Sanford was considering the future of mussel processing in Christchurch. Recent weather patterns had impacted on natural spat (offspring) supply... More>>

ALSO:

Price Of Cheese: Dairy Product Prices Fall To The Lowest This Year

Dairy product prices fell in the latest GlobalDairyTrade auction, hitting the lowest level in the 2015 auctions so far, as prices for milk powder and butter slid amid concern about the outlook for commodities. More>>

ALSO:

Houston, We Have An Air Route: Air New Zealand To Fly Direct To The Heart Of Texas

Air New Zealand will fly its completely refitted Boeing 777-200 aircraft between Auckland and Houston up to five times a week opening up the state of Texas as well as popular nearby tourist states such as Louisiana and Florida. More>>

ALSO:

Scoop Business: Reserve Bank’s Spencer Calls On Govt To Rethink Housing Tax

The Reserve Bank has urged the government to take another look at a capital gains tax on investment in housing, allow increased high-density development and cut red tape for planning consents to address an over-heated Auckland property market. More>>

ALSO:

Get More From Scoop

 
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news