Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Using synthetic biology to make new antibiotics

Using synthetic biology to make new antibiotics


Research at Victoria University of Wellington could lead to a new generation of antibiotics, helping tackle the global issue of ‘superbugs’ that are resistant to modern medicine.

Led by Mark Calcott, who has just completed his PhD study, under the supervision of Dr David Ackerley, an associate professor in the School of Biological Science, the research is delivering new knowledge about how synthetic biology might be used to counter bacteria that have become resistant to existing antibiotics.

The recently published study defines new ways that microbes, which are used to make some commonly used types of antibiotics, can be reengineered to produce modified forms of the original molecules.

“Part of the problem is that people have historically been careless when using antibiotics, which has, one-by-one, allowed bacteria to build resistance, thrive and multiply. We’re smarter now, but at a time when we’re running out of options,” says Dr Ackerley.

“There is a serious and immediate need for new antibiotics—either we have to develop the next generation or find clever and affordable ways of modifying the ones we currently have,” he says.

“The basis of our research is the idea that the microbial machinery (enzymes) that makes a particular antibiotic can be rearranged, to make a different antibiotic that resistant bacteria won’t recognise. The new antibiotics will still fight infection, and if we can use them in a more targeted way, bacteria won’t become resistant so easily.”

He says the ultimate goal of the study is to be able to produce high yields of new and affordable antibiotics that ‘superbugs’ don’t recognise and are not resistant to.

Results have been published by the American Society for Microbiology journal Applied and Environmental Microbiology, viewable online here: http://bit.ly/1jpXM9U

The research is a core output of a grant Dr Ackerley has received from the Marsden Fund for a project called Cracking the non-ribosomal code. Dr Ackerley is collaborating with Professor Iain Lamont from the Department of Biochemistry at Otago University.

ends

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Scoop Business: RBNZ Keeps OCR At 3.5%, Signals Slower Pace Of Future Hikes

Reserve Bank governor Graeme Wheeler kept the official cash rate at 3.5 percent and signalled he won’t be as aggressive with future rate hikes as previously thought as inflation remains tamer than expected. The kiwi dollar fell to a seven-month low. More>>

ALSO:

Weather: Dry Spells Take Hold In South Island

Many areas in the South Island are tracking towards record dry spells as relatively warm, dry weather that began in mid-August continues... for some South Island places, the current period of fine weather is quite rare. More>>

ALSO:

Scoop Business: Productivity Commission To Look At Housing Land Supply

The Productivity Commission is to expand on its housing affordability report with an investigation into improving land supply and development capacity, particularly in areas with strong population growth. More>>

ALSO:

Forestry: Man Charged After 2013 Death

Levin Police have arrested and charged a man with manslaughter in relation to the death of Lincoln Kidd who was killed during a tree felling operation on 19 December 2013. More>>

ALSO:

Smells Like Justice: Dairy Company Fined Over Odour

Dairy company fined over odour Dairy supply company Open Country Dairy Limited has been convicted and fined more than $35,000 for discharging objectionable odour from its Waharoa factory at the time of last year’s ”spring flush” when milk supply was high. More>>

Scoop Business: Dairy Product Prices Decline To Lowest Since July 2012

Dairy product prices dropped to the lowest level since July 2012 in the latest GlobalDairyTrade auction, led by a slump in rennet casein and butter milk powder. More>>

ALSO:

SOE Results: TVNZ Lifts Annual Profit 25% On Flat Ad Revenue, Quits Igloo

Television New Zealand, the state-owned broadcaster, lifted annual profit 25 percent, ahead of forecast and despite a dip in advertising revenue, while quitting its stake in the pay-TV Igloo joint venture with Sky Network Television. More>>

ALSO:

Get More From Scoop

 
 
Computer Power Plus

Standards New Zealand

Standards New Zealand
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news