Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Breakthrough in diabetes research

Breakthrough in diabetes research: single mechanism may cause both types of disease


University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

The common trigger mechanism has been suspected but not proved until now.

Professor Garth Cooper of the University’s School of Biological Sciences and Maurice Wilkins Centre for Molecular BioDiscovery leads an international research team whose latest discovery means we now know what causes beta-cells of the pancreas – cells that make insulin – to die in both type-1 and type-2 diabetes.

The research shows compelling evidence that type-1 diabetes (juvenile onset) and type-2 diabetes are both caused by the formation of tiny toxic clumps of the hormone amylin, which is produced by the same cells in the pancreas which produce insulin.

These small clumps of amylin in turn destroy those cells that produce insulin and amylin. The consequence of this cell death is development of diabetes, where sugar levels in the blood rise, causing damage to organs such as the heart, kidneys, eyes and nerves.

“We are confident this discovery can be used to make new classes of anti-diabetic medicines and hope to have potential medicines ready for entry into clinical trials within the next two years,” Professor Cooper says.

“We aim to treat patients with both forms of the disease with the objective being to stop the death of the insulin-producing cells and the longer-term goal of increasing these cells.”

According to the International Diabetes Federation, the number of people contracting diabetes is expected to reach 592 million by 2035.

But the causal mechanisms for both types of diabetes have remained obscure, making it very difficult to design effective medicines for its prevention or cure.

The research is published in the Journal of the Federation of American Societies for Experimental Biology (FASEB J), a leading international biology journal.

The two common forms of diabetes are type-1, also known as juvenile onset diabetes in which insulin is vital to ensure survival, and type-2, the more common form which is an increasing global health problem.

This work was supported by Endocore Research Associates, the University of Auckland, the NZ Health Research Council, the Ministry of Business, Innovation & Employment, the Maurice & Phyllis Paykel Medical Research Trust, and the Maurice Wilkins Centre for Molecular BioDiscovery.

ends

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Pest Control: Mouse Blitz Team Leaves For Antipodes

The Million Dollar Mouse project to rid Antipodes Island of mice is underway with the departure of a rodent eradication team to the remote nature reserve and World Heritage Area. More>>

Gongs Got: Canon Media Awards & NZ Radio Awards Happen

Radio NZ: RNZ website The Wireless, which is co-funded by NZ On Air, was named best website, while Toby Manhire and Toby Morris won the best opinion general writing section for their weekly column on rnz.co.nz and Tess McClure won the best junior feature writer section. More>>

ALSO:

Pre-Budget: Debt Focus Risks Losing Opportunity To Stoke Economy

The Treasury is likely to upgrade its forecasts for economic growth in Budget 2016 next week but Finance Minister Bill English has already signalled that more of his focus is on debt repayment than on fiscal stimulus or tax cuts... More>>

ALSO:

Fulton Hogan's Heroes: Managing Director Nick Miller Resigns

Fulton Hogan managing director Nick Miller will leave the privately owned construction company after seven years in charge. The Dunedin-based company has kicked off a search for a replacement, and Miller will stay on at the helm until March next year, or until a successor has been appointed and a transition period completed. More>>

ALSO:

Gordon Campbell: On Electricity, Executions, And Bob Dylan

The Electricity Authority has unveiled the final version of its pricing plan for electricity transmission. This will change the way transmission prices (which comprise about 10% of the average power bill) are computed, and will add hundreds of dollars a year to power bills for many ordinary consumers. More>>

ALSO:

Half Empty: Fonterra NZ, Australia Milk Collection Drops In Season

Fonterra Cooperative Group says milk collection is down in New Zealand and Australia, its two largest markets, in the first 11 months of the season during a period of weak dairy prices. More>>

ALSO:

Get More From Scoop

 
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news