Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Breakthrough in diabetes research

Breakthrough in diabetes research: single mechanism may cause both types of disease


University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

The common trigger mechanism has been suspected but not proved until now.

Professor Garth Cooper of the University’s School of Biological Sciences and Maurice Wilkins Centre for Molecular BioDiscovery leads an international research team whose latest discovery means we now know what causes beta-cells of the pancreas – cells that make insulin – to die in both type-1 and type-2 diabetes.

The research shows compelling evidence that type-1 diabetes (juvenile onset) and type-2 diabetes are both caused by the formation of tiny toxic clumps of the hormone amylin, which is produced by the same cells in the pancreas which produce insulin.

These small clumps of amylin in turn destroy those cells that produce insulin and amylin. The consequence of this cell death is development of diabetes, where sugar levels in the blood rise, causing damage to organs such as the heart, kidneys, eyes and nerves.

“We are confident this discovery can be used to make new classes of anti-diabetic medicines and hope to have potential medicines ready for entry into clinical trials within the next two years,” Professor Cooper says.

“We aim to treat patients with both forms of the disease with the objective being to stop the death of the insulin-producing cells and the longer-term goal of increasing these cells.”

According to the International Diabetes Federation, the number of people contracting diabetes is expected to reach 592 million by 2035.

But the causal mechanisms for both types of diabetes have remained obscure, making it very difficult to design effective medicines for its prevention or cure.

The research is published in the Journal of the Federation of American Societies for Experimental Biology (FASEB J), a leading international biology journal.

The two common forms of diabetes are type-1, also known as juvenile onset diabetes in which insulin is vital to ensure survival, and type-2, the more common form which is an increasing global health problem.

This work was supported by Endocore Research Associates, the University of Auckland, the NZ Health Research Council, the Ministry of Business, Innovation & Employment, the Maurice & Phyllis Paykel Medical Research Trust, and the Maurice Wilkins Centre for Molecular BioDiscovery.

ends

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Balance Of Trade: NZ Posts Trade Deficit In October On Falling Dairy Exports

New Zealand’s posted its largest monthly trade deficit for October in six years, while narrowing the shortfall from September, led by a fall in dairy exports to China while all main imports into the country rose. More>>

ALSO:

Gigatown Winner: Plenty Of Positives For Dunedin

Although the city has taken the Gigatown title, along with new ultrafast 1Gbps broadband and funding for $700,000 worth of UFB-related initiatives across the community, Mr Cull says Dunedin has gained so much more through its involvement. More>>

ALSO:

R18: The Warehouse Group Praised For Removing Games

The decision by New Zealand’s largest retailer The Warehouse Group (TW Group), to withdraw stocks of the latest version of Grand Theft Auto V (GTA V) and other R18 games, has been praised by advocacy group Stop Demand Foundation. More>>

ALSO:

Air NZ Wine Awards: Victory For Villa Maria As Pinot Noir Thrills

It was a night to remember as Villa Maria Estate picked up one of the highest accolades of the evening, the O-I New Zealand Reserve Wine of the Show Trophy, at the 28th Air New Zealand Wine Awards. The Villa Maria Single Vineyard Southern Clays Marlborough ... More>>

ALSO:

Future Brighter Money: RBNZ Releases New Bank Note Designs

New Zealand’s banknotes are getting brighter and better, with the Reserve Bank today unveiling more vibrant and secure banknote designs which will progressively enter circulation later next year. More>>

ALSO:

Get More From Scoop

 
 
Standards New Zealand

Standards New Zealand
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news