Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Breakthrough in diabetes research

Breakthrough in diabetes research: single mechanism may cause both types of disease


University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

The common trigger mechanism has been suspected but not proved until now.

Professor Garth Cooper of the University’s School of Biological Sciences and Maurice Wilkins Centre for Molecular BioDiscovery leads an international research team whose latest discovery means we now know what causes beta-cells of the pancreas – cells that make insulin – to die in both type-1 and type-2 diabetes.

The research shows compelling evidence that type-1 diabetes (juvenile onset) and type-2 diabetes are both caused by the formation of tiny toxic clumps of the hormone amylin, which is produced by the same cells in the pancreas which produce insulin.

These small clumps of amylin in turn destroy those cells that produce insulin and amylin. The consequence of this cell death is development of diabetes, where sugar levels in the blood rise, causing damage to organs such as the heart, kidneys, eyes and nerves.

“We are confident this discovery can be used to make new classes of anti-diabetic medicines and hope to have potential medicines ready for entry into clinical trials within the next two years,” Professor Cooper says.

“We aim to treat patients with both forms of the disease with the objective being to stop the death of the insulin-producing cells and the longer-term goal of increasing these cells.”

According to the International Diabetes Federation, the number of people contracting diabetes is expected to reach 592 million by 2035.

But the causal mechanisms for both types of diabetes have remained obscure, making it very difficult to design effective medicines for its prevention or cure.

The research is published in the Journal of the Federation of American Societies for Experimental Biology (FASEB J), a leading international biology journal.

The two common forms of diabetes are type-1, also known as juvenile onset diabetes in which insulin is vital to ensure survival, and type-2, the more common form which is an increasing global health problem.

This work was supported by Endocore Research Associates, the University of Auckland, the NZ Health Research Council, the Ministry of Business, Innovation & Employment, the Maurice & Phyllis Paykel Medical Research Trust, and the Maurice Wilkins Centre for Molecular BioDiscovery.

ends

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Farming: Alliance Plans To Start Docking Farmer Payments

Alliance Group, New Zealand's second-largest meat cooperative, plans to start withholding some stock payments to its farmers from next week to bolster its balance sheet and force suppliers to meet their share requirements. More>>

ALSO:

Gambling: SkyCity First Half Profit Rises 30%, Helped By High Rollers

SkyCity anticipates the Auckland business will benefit from government gaming concessions which were triggered on Nov. 11 in recognition of SkyCity’s $470 million Convention Centre development. Morrison said the concessions would allow the Auckland business to lift its activity during peak period, noting it had a record revenue week over the Christmas and New Year period. More>>

ALSO:

Money For Light: Kiwi Scientists Secure Preferential Access To Synchrotron

Science and Innovation Minister Steven Joyce today announced a three-year investment of $2.8 million in the Australian Synchrotron, the largest piece of scientific infrastructure in the Southern Hemisphere, to secure preferential access for Kiwi scientists. More>>

Telco Industry Report: Investment Hits $1.7 Bln A Year

Investment in the telecommunications sector is $1.7 billion a year, proportionately one of the highest levels in the OECD, according to a report released today on the status of the New Zealand sector. More>>

ALSO:

PGPs: New Programme Sets Sights On Strong Wool

A new collaboration between The New Zealand Merino Company (NZM) and the Ministry for Primary Industries (MPI), announced today, aims to deliver premiums for New Zealand's strong wool sector... More>>

ALSO:

Restrictions Lifted: No Further Tau Flies Found

The Ministry for Primary Industries (MPI) confirms that all restrictions on the movement of fruit and vegetables in Manurewa, Auckland, due to the Tau fly, have been lifted as of 2.26pm on Sunday 7 February. More>>

Crowdfinding: Awaroa Beach To Become Public Land If Appeal Succeeds

Conservation Minister Maggie Barry says a privately-owned beach will become part of the Abel Tasman National Park if an online crowdfunding campaign to buy it succeeds... More>>

ALSO:

Meat Workers Union: Waitangi Mondayisation Flaunted By Large Employer Of Maori

At the AFFCO Talley owned meat plant in Rangiuru, the company has resorted to bullying and threats... saying they could be disciplined and their union sued for an unlawful strike if workers exercise their rights to a paid day off tomorrow. More>>

Earlier:

Get More From Scoop

 
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news