Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Breakthrough in diabetes research

Breakthrough in diabetes research: single mechanism may cause both types of disease


University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

University of Auckland scientists are reporting a major new development in diabetes research with the discovery of a single molecular mechanism they believe triggers both major forms of the disease.

The common trigger mechanism has been suspected but not proved until now.

Professor Garth Cooper of the University’s School of Biological Sciences and Maurice Wilkins Centre for Molecular BioDiscovery leads an international research team whose latest discovery means we now know what causes beta-cells of the pancreas – cells that make insulin – to die in both type-1 and type-2 diabetes.

The research shows compelling evidence that type-1 diabetes (juvenile onset) and type-2 diabetes are both caused by the formation of tiny toxic clumps of the hormone amylin, which is produced by the same cells in the pancreas which produce insulin.

These small clumps of amylin in turn destroy those cells that produce insulin and amylin. The consequence of this cell death is development of diabetes, where sugar levels in the blood rise, causing damage to organs such as the heart, kidneys, eyes and nerves.

“We are confident this discovery can be used to make new classes of anti-diabetic medicines and hope to have potential medicines ready for entry into clinical trials within the next two years,” Professor Cooper says.

“We aim to treat patients with both forms of the disease with the objective being to stop the death of the insulin-producing cells and the longer-term goal of increasing these cells.”

According to the International Diabetes Federation, the number of people contracting diabetes is expected to reach 592 million by 2035.

But the causal mechanisms for both types of diabetes have remained obscure, making it very difficult to design effective medicines for its prevention or cure.

The research is published in the Journal of the Federation of American Societies for Experimental Biology (FASEB J), a leading international biology journal.

The two common forms of diabetes are type-1, also known as juvenile onset diabetes in which insulin is vital to ensure survival, and type-2, the more common form which is an increasing global health problem.

This work was supported by Endocore Research Associates, the University of Auckland, the NZ Health Research Council, the Ministry of Business, Innovation & Employment, the Maurice & Phyllis Paykel Medical Research Trust, and the Maurice Wilkins Centre for Molecular BioDiscovery.

ends

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

Cosmetics & Pollution: Proposal To Ban Microbeads

Cosmetic products containing microbeads will be banned under a proposal announced by the Minister for the Environment today. Marine scientists have been advocating for a ban on the microplastics, which have been found to quickly enter waterways and harm marine life. More>>

ALSO:

NIWA: 2016 New Zealand’s Warmest Year On Record

Annual temperatures were above average (0.51°C to 1.20°C above the annual average) throughout the country, with very few locations observing near average temperatures (within 0.5°C of the annual average) or lower. The year 2016 was the warmest on record for New Zealand, based on NIWA’s seven-station series which begins in 1909. More>>

ALSO:

Farewell 2016: NZ Economy Flies Through 2016's Political Curveballs

Dec. 23 (BusinessDesk) - New Zealand's economy batted away some curly political curveballs of 2016 to end the year on a high note, with its twin planks of a booming construction sector and rampant tourism soon to be joined by a resurgent dairy industry. More>>

ALSO:


NZ Economy: More Growth Than Expected In 3rd Qtr

Dec. 22 (BusinessDesk) - New Zealand's economy grew at a faster pace than expected in the September quarter as a booming construction sector continued to underpin activity, spilling over into related building services, and was bolstered by tourism and transport ... More>>

  • NZ Govt - Solid growth for NZ despite fragile world economy
  • NZ Council of Trade Unions - Government needs to ensure economy raises living standards
  • KiwiRail Goes Deisel: Cans electric trains on partially electrified North Island trunkline

    Dec. 21 (BusinessDesk) – KiwiRail, the state-owned rail and freight operator, said a small fleet of electric trains on New Zealand’s North Island would be phased out over the next two years and replaced with diesel locomotives. More>>

  • KiwiRail - KiwiRail announces fleet decision on North Island line
  • Greens - Ditching electric trains massive step backwards
  • Labour - Bill English turns ‘Think Big’ into ‘Think Backwards’
  • First Union - Train drivers condemn KiwiRail’s return to “dirty diesel”
  • NZ First - KiwiRail Going Backwards for Xmas
  • NIWA: The Year's Top Science Findings

    Since 1972 NIWA has operated a Clean Air Monitoring Station at Baring Head, near Wellington... In June, Baring Head’s carbon dioxide readings officially passed 400 parts per million (ppm), a level last reached more than three million years ago. More>>

    ALSO:

    Get More From Scoop

     
     
     
     
     
     
     
     
    Sci-Tech
    Search Scoop  
     
     
    Powered by Vodafone
    NZ independent news