Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search

 


Revolutionary handheld DNA diagnostic unit

Revolutionary handheld DNA diagnostic unit allows lab-quality analysis in the field

A revolutionary handheld and battery-powered DNA diagnostic device invented at the University of Otago is poised to become a commonly used field tool for rapidly detecting suspected viruses or bacteria in samples while also determining the level of infection.

The breakthrough device, dubbed Freedom4, will be unveiled today at the Queenstown Molecular Biology main meeting. It takes advantage of a technology called quantitative PCR to identify target DNA sequences in real-time, without the need for further processing.

As an example, using Freedom4, the presence and extent of norovirus infection in a sample could be confirmed within less than an hour, while the person using the unit was still at the outbreak site.

Dr Jo-Ann Stanton, who led the programme to develop the device, says that as well as enabling ‘anytime, anywhere’ clinical diagnosis of viral infectious diseases in humans and animals, it also has many other potential uses, such as border security, forensics or environmental monitoring.

Developed by Dr Stanton’s multidisciplinary team at Otago’s Department of Anatomy, the sturdy unit weighs the same as a typical laptop and fits on the palm of your hand. Freedom4 boasts a six-hour battery life and can be tethered to a laptop, or connect wirelessly to smart phones or tablets running custom software that analyses and interprets the test results.

“This mobility could provide a great boon for farmers. For instance, vets could drive around a farm analysing samples from various locations, make their diagnoses and treat infected animals—all in one trip,” she says.

A prototype of the device has been independently put through its paces by the New Zealand Institute of Environmental and Scientific Research. After running assays for toxin-producing E. coli, and several gastrointestinal and respiratory viruses—including H1N1—Freedom4 was found to perform on a par with much larger laboratory-based DNA analysis systems.

Dr Stanton says she and her team are delighted that their six-year project to make a handheld point-of-care diagnostic device a reality has come to fruition.

“We are immensely proud that we have created this brilliant device; there is currently no other system in the world that compares in terms of the analytical power we have achieved at this level of mobility and ease of use.”

Dr Stanton’s team includes a physicist, computer programmer, a chemist and biologists. Their project was funded through a New Economy Research Fund (NERF) grant, from what is now the Ministry of Business, Innovation and Employment. NERF objectives include supporting investigator-initiated basic research that has the potential to create the advanced technological platforms that will underpin new and emerging industries.

The University’s commercialisation arm, Otago Innovation, is now working to spin out the technology in partnership with a New Zealand company named Ubiquitome.

Otago Innovation’s Senior Commercialisation Manager David Christensen says that Freedom4’s development exemplifies university research being successfully translated into real-world technology with enormous potential health, economic and environmental benefits.

“Dr Stanton and her colleagues have used their combined multidisciplinary expertise to overcome a number of daunting technical challenges to create a molecular diagnostic device that is truly world-leading,” Mr Christensen says.

It is another great example of technology transfer from the University of Otago, he says.

“We are delighted to be a part of Ubiquitome as it works to realise its dream of connecting the world to meaningful genomic information through handheld, cloud-connected genetic analysis devices.”

ends

© Scoop Media

 
 
 
 
 
Business Headlines | Sci-Tech Headlines

 

BusinessDesk: SkyCity Lifts Minimum Convention Centre Investment To $430M

SkyCity Entertainment Group, the casino operator, has lifted the minimum it will invest in the Auckland International Convention Centre to $430 million and said total costs including land may be $450 million to $470 million. More>>

Statistics: Drop In Dairy Prices Leads Fall In Exports

Total goods exports fell $240 million (5.5 percent) to $4.2 billion in April 2015 compared with April 2014, Statistics New Zealand said today. More>>

BusinessDesk: APN's NZME Sees Future In Paywalls, Growth In Digital Sales

APN News & Media has touted a single newsroom concept for its NZME unit in New Zealand, similar to what Germany's Die Welt uses, saying an 'integrated sales proposition' is helping it win market share, including ... More>>

Labour Party: Global Milk Prices Now Lowest In 6 Years

The latest fall in the global dairy price has brought it to the lowest level in six years and shows there must be meaningful action in tomorrow’s Budget to diversify the economy, says Labour’s Finance spokesperson Grant Robertson. “Dairy prices ... More>>

BusinessDesk: NZ Inflation Expectations Creep Higher In June Survey

May 19 (BusinessDesk) - New Zealand businesses lifted their expectations for inflation over the next two years, sapping any immediate pressure on the Reserve Bank to cut interest rates, and prompting the kiwi dollar to jump higher. More>>

BusinessDesk: Lower Fuel Costs Drive Down NZ Producer Input, Output Prices

May 19 - Producer input and output prices fell in the first quarter, mainly reflecting lower fuel costs and weakness in prices of meat and dairy products. More>>


Media: Fairfax Media NZ Announces Senior Editorial Team

Fairfax Media New Zealand has today confirmed its new editorial leadership team, as part of a transformation of its newsrooms aimed at enhancing local and national journalism across digital and print. More>>

Science: Flavonoids Reduce Cold And Cough Risk

Flavonoids reduce cold and cough risk Research from the University of Auckland shows eating flavonoids – found in green tea, apples, blueberries, cocoa, red wine and onions – can significantly reduce the risk of catching colds and coughs. The research, ... More>>

BusinessDesk: RBNZ House Alert Speech The Catalyst For Government Action

Prime Minister John Key all but conceded that pressure from the Reserve Bank of New Zealand for concerted action on rampant Auckland house prices was one of the main catalysts for the government's weekend announcements about tightly ... More>>

BusinessDesk: How To Fall Foul Of The New Housing Tax Rules: Tips From IRD

Just because you rented out your investment property doesn't absolve you from paying tax, says the Inland Revenue Department in a summary of commonly made mistakes by non-professional property investors when it comes to their tax liability.More>>

Legal: Superdiversity Law, Policy And Business Stocktake Announced

Mai Chen, Managing Partner at Chen Palmer New Zealand Public and Employment Law Specialists and Adjunct Professor of Law at the University of Auckland, today announced the establishment ... More>>

Housing: More House Price Gains Expected

House price expectations remain high, with a net 56% of respondents expecting house prices will increase. Fears of higher interest rates are fading, consistent with the RBNZ’s signals this year. Affordability and a lack of houses for ... More>>

Get More From Scoop

 
 
 
 
 
 
 
 
 
Sci-Tech
Search Scoop  
 
 
Powered by Vodafone
NZ independent news