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UC Discovery Could Help Monitor Inflammation In Heart Disease And SARS-like Diseases

A University of Canterbury (UC) research team has found that measuring antioxidant chemicals generated by white blood cells is important for monitoring inflammation and free radical damage during diseases such as heart disease or SARS.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals that are associated with many diseases.

UC Biochemist Associate Professor Steven Gieseg, who led the University of Canterbury Biological Sciences research team, says these white blood cell generated chemicals have been found to be some of the first to rise in the blood in response to SARS.

“What we have shown for the first time is how one of these chemicals, called neopterin, is generated. The body’s white blood cells produce various antioxidants to try and protect themselves from the damaging free radicals generated for killing bacteria and virus infected cells.

“We have shown that the white blood cell made antioxidant called dihydroneopterin, rapidly neutralises the toxic oxidants made during inflammation. In doing so, it generates a yellow chemical called neopterin that is easily measured in patients’ blood or urine during disease.

“We think our work explains why a rapid rise in the neopterin is a sign that the patient may die as it showing the body is being overwhelmed by the oxidants generated during some diseases.”

Associate Professor Gieseg says the work paves the way for clinicians to effectively monitor both inflammation and the body damaging oxidative stress during disease.

The findings have recently been published in the leading scientific journal on antioxidant research, Free Radicals Biology and Medicine. The research was funded by a grant from the Heart Foundation of New Zealand.

Associate Professor Gieseg says the work originally focused on vascular disease but he believes the relevance is far wider.

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