Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search


Precision medicine study begins for type 2 diabetes

New Zealand researchers are bringing us closer to a future where people living with type 2 diabetes will be prescribed the best medications for them personalised to their genetics, body size, ethnicity, age and other characteristics.

There are 12 classes of drugs that have been proven in large clinical trials internationally to manage type 2 diabetes. In Aotearoa New Zealand, half of these medications are funded, including the recently funded vildagliptin. The problem is, medications work very differently in different people, and at the moment doctors can only figure out the best match for an individual patient through trial and error.

Associate Professor Rinki Murphy, endocrinologist and researcher at the University of Auckland’s Faculty of Medical and Health Sciences, says a ‘precision medicine’ approach to managing type 2 diabetes, which affects over 200,000 people in New Zealand, would have many benefits.

“Knowing who responds best to each type of diabetes drug would help patients to get more effective medication earlier in their treatment, with fewer negative side effects, and improved health outcomes,” she says.

“The savings made from removing redundant drugs from people’s ever-growing medication cocktails could enable us to fund a greater selection of diabetes medications, if they could be used in a stratified and rational way.”

Dr Murphy is leading a pioneering study to identify which personal factors predict people’s response to two different diabetes drugs: vildagliptin and pioglitazone. The study team of doctors and nurses are looking to recruit 300 people aged 18-80 years with type 2 diabetes who are currently treated with metformin and/or sulfonylurea medications, but still require extra diabetes medication. Funded by the Health Research Council and University-based Maurice Wilkins Centre, the study is running in Auckland, Kaitaia, Tairāwhiti Gisborne and Waikato.

Participants will donate an initial blood sample to check for blood biomarkers including genetics, insulin and lipids (fats), and undergo a general medical assessment. They will then receive either pioglitazone or vildagliptin for four months each, in random order. At the end of the eight months, each participant will receive a summary of their own responses, and personal preference to the two medications, so they can decide with their usual doctor on their long term treatment.

“We are trying to understand whether the glucose-lowering response to these two contrasting medications differs by ethnicity, age, gender, body size, lipids, and genetics,” says Dr Murphy.

“We are particularly interested in whether the response is different among people of Māori and Pacific ancestry, because they are not represented in the international clinical trials evaluating these diabetes medications, and it is possible that due to unique genetics, there may be biological reasons for different metabolism and effectiveness of these drugs among people of different ethnicities.”

Researchers hope that the results of this study, combined with future studies looking at the other diabetes medications, will bring precision medicine to type 2 diabetes in the near future.

People interested in joining the study can email or find out more information on the study page.


© Scoop Media

Business Headlines | Sci-Tech Headlines


Reserve Bank: RBNZ To Implement $30bn Large Scale Asset Purchase Programme Of NZ Govt Bonds

The Monetary Policy Committee (MPC) has decided to implement a Large Scale Asset Purchase programme (LSAP) of New Zealand government bonds. The negative economic implications of the coronavirus outbreak have continued to intensify. The Committee ... More>>


Elevate NZ: Venture Fund To Lift Productivity

The Government’s new $300 million venture capital fund - announced in last year’s Budget – is now open for business as the Elevate NZ Venture Fund. Finance Minister Grant Robertson says lifting New Zealand's productivity requires well-functioning ... More>>


COVID-19: Case Confirmed In NZ – Expert Reaction

After spreading across the globe for months, the first case of COVID-19 has been reported in New Zealand. The Ministry of Health says the risk of a community outbreak is low, due to their preparedness and the high awareness of the disease. The Science ... More>>


Agriculture: New Legislation To Boost Organics

New organics legislation will boost consumer confidence and help grow an innovative sector, says Food Safety Minister Damien O’Connor. “The Organics Product Bill, introduced to Parliament this week, aims to increase consumer confidence when purchasing ... More>>


Biodiversity Policy: Misinformation Circulating

Forest & Bird is concerned at misinformation circulating regarding a policy statement aimed at protecting New Zealand’s unique biodiversity. The National Policy Statement for Indigenous Biodiversity is being consulted on by the ... More>>