Video | Business Headlines | Internet | Science | Scientific Ethics | Technology | Search


Koru Lifescience Preparing To Send Drug Compounds To Preclinical And Clinical Trials Based On Their Study For Covid-19

Koru Life science, drug discovery, and advanced formulation research laboratory in Auckland, New Zealand, has identified several known drug compounds of value in their study for a treatment of Covid-19. The study reports shall be published after a scientific peer review within the next few months.

The finding is currently processed by Koru IP team before entering clinical trials scheduled for Q1 2021.

Joti Jain, Chairman of Koru, explained, "SARS-CoV-2 is an enveloped positive-sense RNA coronavirus, and the mechanisms that this virus uses to gain control of an infected cell and to replicate are not clearly understood. However, it is evident from the studies that this SARS-Cov-2 entirely relies on the cell molecular machinery and cell metabolites to survive and to replicate. Joti explained the survival mechanism of Sars-Cov-2 is what makes it so dangerous.

Sars-Cov-2 constitutes a new threat for the global community and economic growth; considering the Sars-Cov-2 Landscape and the potential impact worldwide, it was a no brainer to engage the resources and expertise towards researching Covid-19 therapy while placing several other research programs on hold. Another critical factor that led to these efforts was a growing concern regarding the availability of treatment and or a vaccine for New Zealand. If the Covid-19 therapy were successful in human trials, this therapy would be offered to New Zealand at cost and priority as New Zealand remains Koru’s priority. A similar offer shall be extended to several other countries facing severe economic and health challenges and might not be in the frontline of getting any vaccine or therapy in the foreseeable future. Further studies are in progress to have more data on the efficacy, dose determinations, and clinical outcome.

It has been less than four months since we have started our research, and our team feels excited about the progress. It is incredible to be at this stage of research, where we have up-and-coming drug candidates that may have the potential to be repurposed for SARS-CoV-2 entry inhibition."

From the initial phase, Koru has maintained a two-pronged approach that focuses equally on the entry inhibition and intracellular replication of Sars-Cov-2. Inhibition of viral entry is critical as Sars-Cov-2 can enter host cells via both endosomal and non-endosomal pathways. With this approach, Koru aims at preventing any escalation or progression of infection and the possibility of a Cytokine storm that may result in inflammatory damage, which is commonly seen in severe cases, explained Akhil Jain, CEO of Koru Lifescience.

Koru's drug research program is about rational drug discovery, focusing on practical and less toxic therapeutics compounds using polypharmacology as an approach; Koru is actively working on several targets. This approach has a significant impact on saving the cost of development, offers therapy for unmet medical needs, and lowers overall healthcare costs.

© Scoop Media

Business Headlines | Sci-Tech Headlines


TradeMe: Property Prices In Every Region Hit New High For The Very First Time

Property prices experienced their hottest month on record in December, with record highs in every region, according to the latest Trade Me Property Price Index.\ Trade Me Property spokesperson Logan Mudge said the property market ended the year with ... More>>

Motor Industry Association: 2020 New Vehicle Registrations Suffer From Covid-19

Chief Executive David Crawford says that like some other sectors of the New Zealand economy, the new vehicle sector suffered from a case of Covid-19. Confirmed figures for December 2020 show registrations of 8,383 were 25% ... More>>

CTU 2021 Work Life Survey: COVID And Bullying Hit Workplaces Hard, Huge Support For Increased Sick Leave

New data from the CTU’s annual work life survey shows a snapshot of working people’s experiences and outlook heading out of 2020 and into the new year. Concerningly 42% of respondents cite workplace bullying as an issue in their workplace - a number ... More>>

Smelter: Tiwai Deal Gives Time For Managed Transition

Today’s deal between Meridian and Rio Tinto for the Tiwai smelter to remain open another four years provides time for a managed transition for Southland. “The deal provides welcome certainty to the Southland community by protecting jobs and incomes as the region plans for the future. The Government is committed to working on a managed transition with the local community,” Grant Robertson said. More>>


University of Auckland: Pest-Free Goal Won’t Be Achieved Without New And Better Tools

New Zealand’s goal to become predator free by 2050 will remain an unrealised dream unless new technologies and advances in social engagement continue to be developed, researchers who first promoted it say. A team from the University of Auckland has ... More>>

OECD: Area Employment Rate Rose By 1.9 Percentage Points In The Third Quarter Of 2020

OECD area employment rate rose by 1.9 percentage points in the third quarter of 2020, but remained 2.5 percentage points below its pre-pandemic level The OECD area [1] employment rate – the share of the working-age population with jobs – rose ... More>>

Economy: Strong Job Ad Performance In Quarter Four

SEEK Quarterly Employment Report data shows a positive q/q performance with a 19% national growth in jobs advertised during Q4 2020, which includes October, November and December. Comparing quarter 4, 2020, with the same quarter in 2019 shows that job ad volumes are 7% lower...More>>

NIWA: 2020 - NZ’s 7th-warmest Year On Record

The nationwide average temperature for 2020, calculated using stations in NIWA’s seven-station temperature series which began in 1909, was 13.24°C (0.63°C above the 1981–2010 annual average). New Zealand’s hottest year on record remains 2016, when... More>>