News Video | Policy | GPs | Hospitals | Medical | Mental Health | Welfare | Search


World Brain Day: NZ at leading edge of migraine research

This year’s World Brain Day today is dedicated to one of the most complex of all neurological disorders that affects millions of people worldwide: migraine.

Recent breakthroughs in treatment with a new class of drugs that, for the first time, prevent migraine rather than treat it after the fact, have been life-changing for many people but they don’t work for everyone.

Leading edge research at the University of Auckland is focused on understanding why these drugs are not always effective by investigating how they interact with a key hormone in the brain and nerves called CGRP.

The new migraine prevention drugs, released in the US last year, work to ‘mop up’ excess CGRP in the bloodstream or by blocking it completely, preventing it from acting on nerve cells. This is life-changing for some people, particularly chronic sufferers who may have more than 15 headache days per month.

CGRP is regarded as a key suspect in causing migraine because it is involved in chemical signalling between cells in the nerves and in the brain. Scientists have known for some time that people who suffer from migraine have elevated levels of, or are more sensitive to, CGRP, which acts as a spark, setting off an attack.

The Auckland team synthesised a fluorescent molecule of CGRP in the laboratory allowing the researchers to investigate in minute detail its interaction with cells in real time under a microscope.

“By successfully creating this CGRP molecule we hope to develop and refine the next wave of treatments to work even better and to understand exactly how these new drugs interact with CGRP in the body,” says PhD candidate Erica Hendrikse, a member of the research team whose mother has suffered severe migraine most of her life.

Erica remembers having to come home from school to ring an ambulance because her mother could not leave her darkened bedroom.

“Mum got them regularly but I definitely remember some being worse than others,” she says. “It feels really important for us to do this work because migraine has such a big impact on people’s lives. It also affects people so differently that even in the scientific world, the condition still has an air of mystery about it.”

The Auckland team includes Professor Debbie Hay, Dame Professor Margaret Brimble and Dr Christopher Walker at the School of Biological Sciences. The team previously discovered there are two ‘receptors’ for CGRP. This work seeks to understand whether they behave differently and if one receptor is more sensitive to CGRP that the other.

© Scoop Media

Culture Headlines | Health Headlines | Education Headlines


Westpac Exiting Cake Tin: Stadium Announces Naming Rights Agreement With Sky

Wellington Regional Stadium Trust (WRST) and Sky Network Television Ltd (Sky) have announced a new partnership that will see Sky secure the naming rights of the Stadium from 1 January 2020. More>>

ASB Classic: Serena Williams Confirmed For 2020

One of the biggest names in sport has confirmed she will be returning to the ASB Classic in 2020. Twenty-three time Grand Slam singles champion Serena Williams will return to Auckland’s ASB Tennis Arena to challenge for the ASB Classic title. More>>

Netball: Taurua To Coach Silver Ferns Through Two More Campaigns

Netball New Zealand has confirmed Taurua will guide the Silver Ferns as they take on the Australian Diamonds in October’s Cadbury Netball Series (Constellation Cup), along with the Northern Quad Series in late January. More>>


Bigger But Less Novel Than The Parrot: Giant Fossil Penguin Find

The discovery of Crossvallia waiparensis, a monster penguin from the Paleocene Epoch (between 66 and 56 million years ago), adds to the list of gigantic, but extinct, New Zealand fauna. These include the world’s largest parrot, a giant eagle, giant burrowing bat, the moa and other giant penguins. More>>



  • Wellington
  • Christchurch
  • Auckland